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The plasmodium parasite digests haemoglobin forming the compound haem which is the non-protein component of haemoglobin and is toxic to cells. Haem is converted by a parasitic polymerase enzyme to the insoluble crystalline form haemozoin that is not toxic to plasmodium. Hydroxychloroquine in Plaquenil tablets mg is thought to act by inhibiting the formation of haemozoin which prevents the detoxification of haem inside the parasitic digestive system and thereby kills the parasite.

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These include inhibition of inflammatory mediators such as interleukins and prostaglandins; also dampening down the immune response by interacting with immune cells that influence the immune response to autoantigens directed against self and by interfering with antigen-processing in antigen presenting cells like macrophages. These combined actions of hydroxychloroquine in Plaquenil tablets mg help slow down the progression of chronic rheumatic diseases, such as acute and chronic arthritis and mild systemic lupus erythematosus SLE and discoid lupus erythematosus DLE , which are thought to be autoimmune diseases when the immune system is directed against self , but it does not act as a cure.


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Plaquenil contains the active ingredient hydroxychloroquine sulfate mg, the antimalarial and disease-modifying antirheumatic drug DMARD used to treat malaria, rheumatoid arthritis, systemic lupus erythematosus and discoid lupus erythematosus. They also contain: calcium hydrogen phosphate, maize starch, purified water, and magnesium stearate.

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The film coating contains small amounts of hypromellose, macrogol , titanium dioxide, polysorbate 80, carnauba wax, black ink Tekprint SBSD , and purified water. Plaquenil tablets mg are used to treat malaria, an infection caused by the protozoan single cell parasitic organism Plasmodium. The most common forms of plasmodium are P. The parasite is carried by mosquitoes and is transmitted by a bite from an infected female mosquito when the first stage of the life cycle called the sporozoite is injected into the blood while the mosquito is feeding.

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It then migrates to the liver, where it matures into schizonts and multiplies. The next stage of the plasmodium life cycle called merozoite is released into the blood, infects red blood cells and transforms into the trophozoite that causes destruction of red blood cells. Some merozoites transform into gametocytes and are taken up by a mosquito when feeding on blood to begin a new cycle. Symptoms of malaria, including fever, shivering, headache, vomiting, muscle pain, and joint pain, usually appear 10 to 15 days after the mosquito bite.

However, if left untreated, malaria can quickly become life-threatening, causing anaemia and brain damage and disrupting the blood supply to vital organs. Plaquenil tablets mg contain the antimalarial hydroxychloroquine, which is active against the trophozoite stage of the plasmodium parasitic life cycle that infects red blood cells and causes their destruction.

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