Early laboratory research and anecdotal reports about using it for people with COVID have shown encouraging signs that it may work to fight the virus. As dozens of drug companies rush into research projects to develop antibodies and other next-generation therapeutics, chloroquine stands out as a potentially simple, cheap, and scalable treatment, though we haven't yet seen data from any randomized clinical trials, the gold standard of medical research.
One of the three authors of that article was Didier Raoult, a prominent infectious-disease expert who ran a small clinical trial in France testing hydroxychloroquine in a few dozen COVID patients. It's one of many clinical studies around the world testing chloroquine or hydroxychloroquine. Early reports of Raoult's trial were positive, with Raoult saying chloroquine appeared to shorten the time that people with COVID are infectious. Never miss out on healthcare news. Subscribe to Dispensed , Business Insider's weekly newsletter on pharma, biotech, and healthcare.
When combined with the antibiotic azithromycin, it also reduced the viral load in these patients, he added. Azithromycin helps fight lung infections that can come with COVID and may play a role in fighting the virus, Medscape reported. This French study is one small, low-quality study that needs to be replicated on a larger scale. It tested a very small group with no long-term follow up data, and six patients dropped out early and were excluded from the main analysis.
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The French goverment is expanding this testing to see if the results hold up. While experts caution against anyone reaching conclusions about the drug's utility in COVID, President Donald Trump has repeatedly touted chloroquine by name as a promising potential treatment.
On Thursday, US Food and Drug Administration Commissioner Stephen Hahn said chloroquine and hydroxycholoroquine will be made available to patients under a compassionate-use program as more data is collected. Compassionate-use programs are generally for terminally ill patients who have no other treatment options. They allow doctors to give patients treatments that have not proven to be safe and effective. Hydroxychloroquine isn't a benign drug either. Self-medicating can be fatal. An Arizona man died after deciding to take a non-pharmaceutical version of chloroquine used to clean fish tanks.
That includes remdesivir, an antiviral drug being developed by the giant biotech company Gilead Sciences that World Health Organization officials have called "the most promising candidate" for COVID treatment. He recently analyzed the early evidence for three top drugs being tested for COVID — remdesivir, chloroquine, and Kaletra, an HIV drug sold by AbbVie — and concluded that chloroquine was the most promising candidate. Early reports about chloroquine's effectiveness have also caught the attention of Elon Musk.
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