Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, cautioned that the evidence supporting the drug was anecdotal — and that it would take a large, well-done clinical trial to prove its effectiveness. After the release of a small clinical trial in France, Trump also trumpeted combining hydroxychloroquine with the antibiotic azithromycin, which is sold under the brand name Zithromax.
These Drugs Are Helping Our Coronavirus Patients - WSJ
In a press conference the following day, Trump exaggerated the existing evidence for the pharmaceuticals being sent to New York state for COVID clinical trials. Now, again, you know, some doctors think it should go for years in testing. But we think it might work on this, based on evidence — based on very strong evidence.
Trump is entitled to his opinion of how the trials will turn out, but he overstates the evidence supporting the drugs, which is slim. At least two studies have found that hydroxychloroquine has antiviral effects against the new coronavirus, or SARS-CoV-2, in cells grown in the lab.
Publishing in Clinical Infectious Diseases on March 9, researchers in Beijing found that hydroxychloroquine was better than chloroquine in preventing the virus from replicating in cultured monkey cells. Another Chinese group reported on March 18 that hydroxychloroquine blocked entry of the virus into the same kind of cultured cells, and also appeared to prevent the virus from being released from cells.
152 comments on “Chloroquine, Past and Present”
The drug, however, was less effective against the novel coronavirus than chloroquine. In the past, for example, chloroquine has been found to inhibit a variety of viruses in cells, including influenza and chikungunya.
In fact, in nonhuman primates, chloroquine treatment made their chikungunya infections worse, not better. Full Story. Videos show impact of novel coronavirus pandemic on Bay Area.
Doctors warn of health risks of drugs seen as promising for coronavirus
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Coronavirus and chloroquine: Has its use been approved in US?
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