If you are sunburned. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. Very bad skin irritation. Any rash. Side effect or health problem is not better or you are feeling worse.
Sometimes drugs are not safe when you take them with certain other drugs and food.
Store in a cool, dry place away from the reach of children. Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Out of Stock. Your current locality is "Bala Nagar, Hyderabad". To change your current locality Click here. Default locality will be selected as "Bala Nagar, Hyderabad". Please enter verification code OTP sent to:. Existing User of MedPlus? Sign In. Notifications Delete All. Composition Hydroxychloroquine sulphate MG. Patients with glucosephosphate dehydrogenase deficiency may be at particularly high risk for adverse hematologic effects.
Specifically, the risk for QTc-prolongation and the risk for convulsions may be increased. Mefloquine may increase the serum concentration of Aminoquinolines Antimalarial. Management: Avoid concurrent use, and delay administration of mefloquine until at least 12 hours after the last dose of an aminoquinoline antimalarial when possible. Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. Patients with additional risk factors for QTc prolongation may be at even higher risk.
Quinolones may diminish the therapeutic effect of Blood Glucose Lowering Agents. Specifically, if an agent is being used to treat diabetes, loss of blood sugar control may occur with quinolone use. Specifically, concomitant use of tamoxifen and hydroxychloroquine may increase the risk of retinal toxicity. CBC at baseline and periodically; liver function; renal function in patients at risk for ocular toxicity ; blood glucose if symptoms of hypoglycemia occur ; muscle strength especially proximal, as a symptom of neuromyopathy during long-term therapy.
Ophthalmologic exam at baseline fundus examination within the first year plus visual fields and spectral-domain optical coherence tomography [SD OCT] if maculopathy is present to screen for retinal toxicity, followed by annual screening beginning after 5 years of use or sooner if major risk factors are present Marmor [AAO ]. Additionally, the manufacturer recommends an ocular exam include best corrected distance visual acuity and an automated threshold visual field of the central 10 degrees 24 degrees in patients of Asian ancestry as retinal toxicity may appear outside of the macula.
Consider annual exams without deferring 5 years in patients with significant risk factors. Data suggest that individual blood concentrations do not correlate closely with dosage, weight, or clinical effectiveness. However, blood levels may be useful in patients with renal disease or as an aid in assessing compliance Melles Obtain CBC baseline and periodically , renal function tests, and liver function tests.
Obtain ophthalmologic exam at baseline and annually after 5 years of use. Assess muscle strength during prolonged therapy. Assess for signs of cardiomyopathy, bone marrow suppression, neuromuscular effects, and retinal toxicity. Check ordered labs and report abnormalities. Instruct patient on importance of ophthalmic exams.
Monitor for neuromuscular [deep tendon reflexes, muscle weakness] and ocular changes; instruct patient to report.
Anti Malarial Drugs
Excipient information presented when available limited, particularly for generics ; consult specific product labeling. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly. Interferes with digestive vacuole function within sensitive malarial parasites by increasing the pH and interfering with lysosomal degradation of hemoglobin; inhibits locomotion of neutrophils and chemotaxis of eosinophils; impairs complement-dependent antigen-antibody reactions.
Metabolism: Hepatic; metabolites include bidesethylchloroquine, desethylhydroxychloroquine, and desethylchloroquine McChesney Modeling drug passage into human milk.
Clin Pharmacol Ther. Cansu DU, Korkmaz C. Hypoglycaemia induced by hydroxychloroquine in a non-diabetic patient treated for RA. Rheumatology Oxford. Cappellini MD, Fiorelli G.
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Glucosephosphate dehydrogenase deficiency. Centers for Disease Control and Prevention. Electroretinograms of children born to mothers treated with hydroxychloroquine during pregnancy and breast-feeding: comment on the article by Costedoat-Chalumeau et al. Arthritis Rheum. Graefes Arch Clin Exp Ophthalmol. BSR and BHPR guideline on prescribing drugs in pregnancy and breastfeeding-Part I: standard and biologic disease modifying anti-rheumatic drugs and corticosteroids.
Glader B. Diagnosis and management of glucosephosphate dehydrogenase deficiency. Post TW, ed. Accessed November 20, The EULAR points to consider for use of antirheumatic drugs before pregnancy, and during pregnancy and lactation. Ann Rheum Dis. Ito S. Drug therapy for breast-feeding women. N Engl J Med. Proceedings from the American College of Rheumatology Reproductive Health Summit: the management of fertility, pregnancy, and lactation in women with autoimmune and systemic inflammatory diseases.
Arthritis Care Res Hoboken. Kumar P, Banik S. Pharmacotherapy options in rheumatoid arthritis. Systemic lupus erythematosus: primary care approach to diagnosis and management. Am Fam Physician. GlucosePhosphate Dehydrogenase Deficiency. Hematol Oncol Clin North Am. Revised recommendations on screening for chloroquine and hydroxychloroquine retinopathy. Recommendations on screening for chloroquine and hydroxychloroquine retinopathy revision. Nat Clin Pract Rheumatol.
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Studies of the metabolism of some compounds of the 4-aminochloroquinolone series. J Pharmacol Exp Ther. JAMA Ophthalmol. Antimalarial agents in pregnancy. Follow-up of infants exposed to hydroxychloroquine given to mothers during pregnancy and lactation. J Perinatol. Excretion of hydroxychloroquine in human milk. Br J Clin Pharmacol. Therapies for active rheumatoid arthritis after methotrexate failure.
Plaquenil hydroxychloroquine [prescribing information]. Plaquenil hydroxychloroquine [product monograph]. Rath T, Rubbert A. Drug combinations with methotrexate to treat rheumatoid arthritis. Clin Exp Rheumatol. Rheumatoid arthritis medications and lactation.