Hydroxychloroquine 400mg dosage

Even though hydroxychloroquine is an anti-malarial drug, don't assume it will protect you if you're travelling to an area where there's a risk of malaria. Always check with a healthcare professional what precautions you need to take against malaria. Methotrexate is a DMARD used to treat rheumatoid arthritis, juvenile idiopathic arthritis, vasculitis and psoriatic arthritis.

Learn the risks and side-effects. However, if you're also taking methotrexate you should keep well within the recommended limits no more than 14 units of alcohol per week for adults as methotrexate can interact with alcohol and affect your liver.

Information for Clinicians on Therapeutic Options for COVID-19 Patients

In some circumstances your doctor may advise lower limits. We suggest you discuss your medication with your doctor if you're planning to have a baby, become pregnant or are thinking of breastfeeding. Current guidelines state that hydroxychloroquine can be taken during pregnancy.

It's often best to continue with it to prevent a flare-up of your condition as the benefits usually outweigh any possible risks. You can also breastfeed while you're on hydroxychloroquine. Hardly any of the drug passes into the breast milk and there's no evidence it has any effect on the baby. We use cookies to give you the best experience. By continuing to browse this site you are agreeing to our use of cookies.


Call Our Helpline Drugs Hydroxychloroquine. Share on Facebook Tweet LinkedIn. What is hydroxychloroquine? Uses Hydroxychloroquine is used to treat: rheumatoid arthritis discoid and systemic lupus erythematosus SLE juvenile idiopathic arthritis JIA. Are there any reasons I won't be prescribed hydroxychloroquine? How is it taken? Hydroxychloroquine is taken in tablet form, with or after food. How long does it take to work? Because it's a long-term treatment it's important to keep taking hydroxychloroquine unless you have severe side effects: even if it doesn't seem to be working at first even when your symptoms improve to help keep the disease under control.

Side effects and risks Side effects aren't common. However, in some people hydroxychloroquine can cause: skin rashes, especially those made worse by sunlight feeling sick nausea or indigestion diarrhoea headaches bleaching of the hair or mild hair loss tinnitus ringing in the ears visual problems.

A Potential Cure for Coronavirus? FDA approves clinical trial of hydroxychloroquine for COVID-19!

You should report any new eye symptoms to your doctor straight away. Effects on other treatments Hydroxychloroquine is commonly used alongside other disease-modifying drugs including methotrexate — especially for rheumatoid arthritis. You can carry on taking a non-steroidal anti-inflammatory drug NSAID or painkillers , if needed, unless your doctor advises otherwise. Don't take over-the-counter preparations or herbal remedies without discussing this first with your healthcare team. Vaccinations You can have vaccinations, including live vaccines such as yellow fever and shingles, while you're on hydroxychloroquine.

Related information Methotrexate Methotrexate is a DMARD used to treat rheumatoid arthritis, juvenile idiopathic arthritis, vasculitis and psoriatic arthritis.

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Alcohol There's no known interaction between alcohol and hydroxychloroquine. Visual symptoms may present as paracentral scotomas islands of vision loss when reading. If blurring or vision changes occur, hydroxychloroquine should be ceased, and a careful eye examination conducted. Nausea, vomiting, and diarrhoea are common side effects, but are usually transient or resolve on the reduction of the dose. They can be minimised by taking the hydroxychloroquine with food.

Transverse pigmented nail bands and mucosal pigmentation have also been reported. If a rash appears, hydroxychloroquine should be withdrawn and may be restarted at a lower dose. Haematological side effects are rare. Haemolysis in patients with glucosephosphate dehydrogenase G6PD deficiency, aplastic anaemia , and leukopenia has been reported. The most extensive study to date evaluating G6PD deficiency with concurrent use of hydroxychloroquine reported no episodes of haemolysis in over months of exposure among the 11 studied patients with G6PD deficiency.

Routine screening for G6PD deficiency is no longer recommended for hydroxychloroquine. Hydroxychloroquine does cross the placenta and is considered Category D in pregnancy see DermNet NZ's pages on Safety of medicines taken during pregnancy and on Lactation and the skin.

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However, in multiple studies, hydroxychloroquine use has not been associated with congenital disabilities, stillbirth, prematurity, low birth weight, fetal death, or retinopathy following maternal intake at recommended doses. International experts currently recommend that hydroxychloroquine can continue during pregnancy and breastfeeding. Hydroxychloroquine is regarded as safer than chloroquine if required in women planning a pregnancy or breastfeeding.

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The amount of monitoring with hydroxychloroquine varies from centre to centre. More frequent surveillance is needed if laboratory values are abnormal or with high-risk patients. Hydroxychloroquine levels can be measured in the blood. This can potentially be used for monitoring the patient's adherence to treatment and where the response has been inadequate. No standardised effective reference level has been validated.


See smartphone apps to check your skin. DermNet NZ does not provide an online consultation service. If you have any concerns with your skin or its treatment, see a dermatologist for advice. Hydroxychloroquine — codes and concepts open. Hydroxychloroquine sulphate.

Hydroxychloroquine: MedlinePlus Drug Information

Treatment or procedure. New Zealand approved datasheets are the official source of information for prescription medicines, including approved uses and risk information. Check the individual New Zealand datasheet on the Medsafe website. References Browning DJ. Pharmacology of chloroquine and hydroxychloroquine. In: Browning DJ ed. Hydroxychloroquine and chloroquine retinopathy.

New York: Springer, 35— Antimalarials in dermatology: mechanism of action, indications, and side effects. Actas Dermosifiliogr ; — DOI: New concepts in antimalarial use and mode of action in dermatology. Dermatol Ther ; — The epidemiology of atherosclerotic cardiovascular disease among patients with SLE: a systematic review. Semin Arthritis Rheum ; 77— Low-dose hydroxychloroquine is as effective as phlebotomy in treatment of patients with porphyria cutanea tarda.

Clin Gastroenterol Hepatol ; —9. PubMed Wolverton SE. Comprehensive dermatologic drug therapy, 3rd edn. Philadelphia: Elsevier Saunders, Recommendations on screening for chloroquine and hydroxychloroquine retinopathy revision. Ophthalmology ; — Examination of hydroxychloroquine use and hemolytic anemia in G6PDH-deficient patients. Arthritis Care Res ; —5. Follow-up of infants exposed to hydroxychloroquine given to mothers during pregnancy and lactation. J Perinatol ; 86—9. Ocular toxicity and antenatal exposure to chloroquine or hydroxychloroquine for rheumatic diseases.