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  1. Hydroxychloroquine (Plaquenil®) Drug Information Sheet.
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Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Swallow the tablet whole.

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Do not crush, break, or chew it. Take this medicine with meals or milk to lessen stomach upset, unless otherwise directed by your doctor. Keep using this medicine for the full treatment time, even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon. If you are also taking kaolin or antacids, take them at least 4 hours before or after using hydroxychloroquine.

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The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label.

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The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Treating Lupus with Anti-Malarial Drugs

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

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Manufacturers recommend regular ophthalmological examination but the evidence of practical value is unsatisfactory see advice of the Royal College of Ophthalmologists. To avoid excessive dosage in obese patients, the dose of hydroxychloroquine should be calculated on the basis of ideal body-weight.


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Other drugs classified as disease-modifying anti-rheumatic drugs. Acute porphyrias ; diabetes may lower blood glucose ; elderly ; G6PD deficiency ; may aggravate myasthenia gravis ; may exacerbate psoriasis ; neurological disorders especially in those with a history of epilepsy—may lower seizure threshold ; severe gastro-intestinal disorders Cautions, further information Screening for retinopathy A review group convened by the Royal College of Ophthalmologists has updated guidelines on screening for chloroquine and hydroxychloroquine retinopathy Hydroxychloroquine and Chloroquine Retinopathy: Recommendations on Screening Individual interactants: Hydroxychloroquine.

Common or very common Abdominal pain ; appetite decreased ; diarrhoea ; emotional lability ; headache ; nausea ; skin reactions ; vision disorders ; vomiting.


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Uncommon Alopecia ; corneal oedema ; dizziness ; eye disorders ; hair colour changes ; nervousness ; neuromuscular dysfunction ; retinopathy ; seizure ; tinnitus ; vertigo. Frequency not known Acute hepatic failure ; agranulocytosis ; anaemia ; angioedema ; bone marrow disorders ; bronchospasm ; cardiac conduction disorders ; cardiomyopathy ; hearing loss ; hypoglycaemia ; leucopenia ; movement disorders ; muscle weakness ; myopathy ; photosensitivity reaction ; psychosis ; reflexes absent ; severe cutaneous adverse reactions SCARs ; thrombocytopenia ; tremor ; ventricular hypertrophy.

Overdose Hydroxychloroquine is very toxic in overdosage; overdosage is extremely hazardous and difficult to treat. Avoid—risk of toxicity in infant.

Manufacturer advises caution. Manufacturer advises consider dose adjustment in severe impairment. Monitor plasma-hydroxychloroquine concentration in severe renal impairment.